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We make no claims regarding the medicinal, preventive or curative properties of wolfberries (lycium barbarum). This product is not intended to diagnose, treat, cure, or prevent disease. The wolfberry fruit has been used in traditional Chinese medicine (TCM) for more than 2000 years. Modern scientists have been researching the potential of wolfberries (lycium barbarum) over the past 20 years. Scroll down to see these research articles posted on the National Institutes of Health (NIH.GOV) website.

 

Lycium barbarum Polysaccharides Improve Testicular Spermatogenic Function in Streptozotocin-Induced Diabetic Rats

2020 Apr 17 Abstract

The objective of this study was to investigate the protective effects of Lycium barbarum polysaccharides (LBP) on testicular spermatogenic function in streptozotocin (STZ)-induced diabetic rats. Compared to the control group, blood glucose levels were significantly increased and the insulin resistance was markedly aggravated in STZ-induced diabetic rats. Further, the weight of testis and epididymis and the sperm number and motility were decreased in diabetic rats. Pathological changes were also observed in the spermatogenic tubules, along with a decreased number of spermatogenic cells, downregulated proliferating cell nuclear antigen (PCNA) expression, and increased cell apoptosis in the testes. Compared to the saline-treated diabetic rat group, metformin and LBP treatment significantly decreased the level of blood glucose and improved insulin resistance and testicular function. After treatment with metformin and LBP, the pathological changes in the spermatogenic tubules improved significantly, with an increase in the number of spermatogenic cells, upregulation of PCNA, and suppression of apoptosis in the testes. The expressions of sirtuin 1 (SIRT1) and hypoxia-inducible factor 1-alpha (HIF-1α) in diabetic testes were also upregulated by metformin or LBP treatment. In summary, LBP exerted protective effects by increasing cell proliferation, inhibiting cell apoptosis, and regulating SIRT1/HIF-1α expression in the testes of diabetic rats.

https://pubmed.ncbi.nlm.nih.gov/32362869/

 

An evidence-based update on the pharmacological activities and possible molecular targets of Lycium barbarum polysaccharides

2014 Dec 17 Abstract

Lycium barbarum berries, also named wolfberry, Fructus lycii, and Goji berries, have been used in the People's Republic of China and other Asian countries for more than 2,000 years as a traditional medicinal herb and food supplement. L. barbarum polysaccharides (LBPs) are the primary active components of L. barbarum berries and have been reported to possess a wide array of pharmacological activities. Herein, we update our knowledge on the main pharmacological activities and possible molecular targets of LBPs.

 

  • Several clinical studies in healthy subjects show that consumption of wolfberry juice improves general wellbeing and immune functions.
  • LBPs are reported to have antioxidative and antiaging properties in different models. LBPs show antitumor activities against various types of cancer cells and inhibit tumor growth in nude mice through induction of apoptosis and cell cycle arrest.
  • LBPs may potentiate the efficacy of lymphokine activated killer/interleukin-2 combination therapy in cancer patients.
  • LBPs exhibit significant hypoglycemic effects and insulin-sensitizing activity by increasing glucose metabolism and insulin secretion and promoting pancreatic β-cell proliferation.
  • They protect retinal ganglion cells in experimental models of glaucoma.
  • LBPs protect the liver from injuries due to exposure to toxic chemicals or other insults.
  • They also show potent immunoenhancing activities in vitro and in vivo.
  • Furthermore, LBPs protect against neuronal injury and loss induced by β-amyloid peptide, glutamate excitotoxicity, ischemic/reperfusion, and other neurotoxic insults.
  • LBPs ameliorate the symptoms of mice with Alzheimer's disease and enhance neurogenesis in the hippocampus and subventricular zone, improving learning and memory abilities.
  • They reduce irradiation- or chemotherapy-induced organ toxicities.
  • LBPs are beneficial to male reproduction by increasing the quality, quantity, and motility of sperm, improving sexual performance, and protecting the testis against toxic insults.
  • Moreover, LBPs exhibit hypolipidemic, cardioprotective, antiviral, and antiinflammatory activities.

 

There is increasing evidence from preclinical and clinical studies supporting the therapeutic and health-promoting effects of LBPs, but further mechanistic and clinical studies are warranted to establish the dose-response relationships and safety profiles of LBPs.

https://pubmed.ncbi.nlm.nih.gov/25552899/

 

*These statements have not been evaluated by the Food and Drug Administration.

This product is not intended to diagnose, treat, cure, or prevent disease.